HLA-B27 antigen

HLA-B27 waa baaritaan dhiig si loo raadiyo borotiin laga helo dusha sare ee unugyada dhiigga cad. Borotiinka waxaa lagu magacaabaa aadanaha leukocyte antigen B27 (HLA-B27).

Human leukocyte antigens (HLAs) waa borotiinno ka caawiya habka difaaca jirka inuu sheego farqiga u dhexeeya unugyadiisa iyo walxaha shisheeye, waxyeelada leh. Waxaa laga sameeyaa tilmaamaha hiddo-wadaha la dhaxlo.

Sambal dhiig ayaa loo baahan yahay. Inta badan, dhiig ayaa laga soo qaataa xididka ku yaal gudaha xusulka ama dhabarka gacanta.

Xaaladaha badankood, looma baahna tillaabooyin gaar ah oo loogu diyaar garoobo imtixaanka.

Marka irbadda loo geliyo si dhiig u soo qaado, waxaad dareemi kartaa xanuun dhexdhexaad ah, ama keliya cirbad ama xinjixin. Ka dib, waxaa jiri kara xoogaa wax garaaca.

Bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu amro baaritaankaan si looga caawiyo go'aaminta waxa keena kalagoys xanuun, qallafsanaan, ama barar. Tijaabada waxaa lagu sameyn karaa baaritaano kale, oo ay ka mid yihiin:

• C-fal-celinta protein
• Qiyaasta qanjirka 'Erythrocyte' (ESR)
• Cudurka rheumatoid
• Raajo

Baaritaanka HLA waxaa sidoo kale loo isticmaalaa in lagu waafajiyo nudaha la tabarucay iyo midka qofka oo helayaa xubin xubin. Tusaale ahaan, waa la samayn karaa markii qofku u baahan yahay beerista kelyaha ama xubin dhuuxa loo beddelo.

Natiijo caadi ah (taban) waxay la micno tahay HLA-B27 inuu maqan yahay.

Tijaabada saxda ah waxaa loola jeedaa HLA-B27 way jirtaa. Waxay soo jeedinaysaa halista ka-celceliska-weyn ee soo-saarka ama yeelashada xanuunno is-beddel ah oo qaarkood. Ciladda isdifaaca jirka waa xaalad dhacda marka nidaamka difaaca jirka uu si qalad ah u weeraro una baabi'iyo unugyada jirka ee caafimaadka qaba.

Natiijo wax ku ool ahi waxay ka caawin kartaa bixiyahaaga inuu sameeyo ogaanshaha nooc ka mid ah arthritis-ka loo yaqaan 'spondyloarthritis'. Noocan ah arthritis-ka waxaa ka mid ah cilladaha soo socda:

• Cudurka 'ankylosing spondylitis'
• Arthritis-ka la xidhiidha cudurka Crohn ama ulcerative colitis
• Cudurka 'Psoriatic arthritis' (arthritis la xiriira cudurka psoriasis)
• Arthritis-ka falcelinta leh
• Sacroiliitis (caabuq ku dhaca wadajirka sacroiliac)
• Cudurka 'Uveitis'

Haddii aad leedahay calaamado ama astaamaha cudurka loo yaqaan 'spondyloarthritis', baaritaanka HLA-B27 ee wanaagsan ayaa laga yaabaa inuu kaa caawiyo xaqiijinta cudurka. Si kastaba ha noqotee, HLA-B27 waxaa laga helaa dadka qaar ee caadiga ah oo had iyo jeer macnaheedu maahan inaad qabtid cudur.

Khataraha in dhiig lagaa qaado waa yar yihiin, laakiin waxaa ka mid noqon kara:

• Dhiigbax xad dhaaf ah
• Miyir beelid ama dareemid madax-wareer
• Hematoma (dhiig ku ururaya maqaarka hoostiisa)
• Infekshan (halis yar mar kasta oo maqaarku jabo)

Bini-aadamka leukocyte antigen B27; Cudurka 'Ankylosing spondylitis-HLA'; Cudurka 'Psoriatic arthritis-HLA'; Arthritis-ka falcelinta-HLA

• Baaritaanka dhiigga

Chernecky CC, Berger BJ. Human Leukocyte Antigen (HLA) B-27 - dhiig. Gudaha: Chernecky CC, Berger BJ, eds. Tijaabooyinka Shaybaarka iyo Nidaamyada Baadhista. 6aad ed. St Louis, MO: Elsevier Saunders; 2013: 654-655.

Fagoaga OR. Bini'aadamka leukocyte antigen: dhismaha ugu weyn ee isku-dhafan ee nin. Gudaha: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis iyo Maareynta Hababka Shaybaarka. 23aad ed. St Louis, MO: Elsevier; 2017: cutubka 49.

Inman RD. Spondyloarthropathies. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 25aad. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 265.

McPherson RA, Massey HD. Dulmarka guud ee nidaamka difaaca jirka iyo cilladaha difaaca jirka. Gudaha: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis iyo Maareynta Hababka Shaybaarka. 23aad ed. St Louis, MO: Elsevier; 2017: cutubka 43.

Muuji JD. Spondyloarthritis. Gudaha: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, AW AJ, Weyand CM, eds. Immunology Clinical: Mabaadi'da iyo Tababarka. 5aad. Philadelphia, PA: Elsevier; 2019: cutubka 57.