Soosaarka xad-dhaafka ah ee ugxanta ee androgens

Soosaarka ugxanta ee 'androgens' waa xaalad ay ugxantu ku samayso testosterone aad u badan. Tani waxay horseed u tahay horumarinta astaamaha labka ah ee dumarka. Androgens ka yimaada qaybaha kale ee jirka ayaa sidoo kale sababi kara astaamaha labka inay ku soo baxaan haweenka.

Haweenka caafimaadka qaba, ugxan sidayaasha iyo qanjidhada adrenal waxay soo saaraan qiyaastii 40% ilaa 50% oo ah testosterone jirka. Burooyinka ugxan-sideyaasha iyo polycystic ugxansidaha cilladda (PCOS) labaduba waxay sababi karaan wax soo saar aad u tiro badan oo androgen ah.

Cudurka 'Cushing' waa dhibaato qanjirka 'pituitary gland' kaas oo keena xaddi badan oo corticosteroids ah. Corticosteroids waxay sababaan isbeddelada jirka ee ragga. Burooyinka ku jira qanjidhada adrenal sidoo kale waxay sababi karaan wax soo saar aad u tiro badan oo ah androgens waxayna u horseedi karaan astaamaha jirka ee ragga dumarka.

Heerarka sare ee androgens-ka dumarka ayaa sababi kara:

• Finanka
• Isbedelada qaabka jirka dumarka
• Hoos u dhig cabirka naaska
• Kordhinta timaha jirka qaab lab ah, sida wajiga, garka, iyo caloosha
• Muddooyinka caadada oo yaraada (amenorrhea)
• Maqaarka saliida leh

Isbedeladaan sidoo kale way dhici karaan:

• Kordhinta cabirka kintirka
• Qoto dheerida codka
• Kordhinta murqaha
• Timo khafiif ah iyo timo lumis xaga hore ee madaxa labada dhinac ee madaxa

Bixiyahaaga daryeelka caafimaadka ayaa sameyn doona baaritaan jireed. Dhiig kasta iyo baaritaanada sawir qaadashada ee la dalbado waxay ku xirnaan doonaan astaamahaaga, laakiin waxaa ka mid noqon kara:

• 17-hydroxyprogesterone baaritaanka
• Imtixaanka ACTH (wax aan caadi ahayn)
• Baaritaanka dhiigga kolestaroolka
• CT iskaanka
• Baaritaanka dhiigga ee DHEA
• Tijaabada gulukooska
• Tijaabada insulin
• Ultrasound-ka miskaha
• Baadhitaanka 'prolactin' (haddii muddooyinku soo yaraadaan ama aaney dhammaanba)
• Tijaabada tijaabada (labadaba bilaash iyo wadar testosterone)
• Tijaabada TSH (haddii timo lumiso)

Daaweyntu waxay kuxirantahay dhibaatada sababa wax soo saarka koritaanka androgen. Daawooyinka waxaa la siin karaa si loo yareeyo wax soo saarka timaha ee haweenka timaha jirka ee xad-dhaafka ah, ama in la nidaamiyo wareegyada caadada. Xaaladaha qaarkood, qalliin ayaa loo baahan karaa si looga saaro ugxan-sidaha ugxan sidaha ama 'adrenal buro'.

Guusha daaweyntu waxay kuxirantahay sababta soosaarka xad-dhaafka ah ee orrogen Haddii xaaladdu ay sababto buro ugxan-sidaha, qalliin looga saarayo buro ayaa laga yaabaa inay saxdo dhibaatada. Badi burooyinka ugxansiduhu ma laha kansar (benign) mana soo laaban doonaan marka laga saaro.

Cudurka ugxan-sidaha ee loo yaqaan 'polycystic ovary syndrome', tallaabooyinka soo socda ayaa yareyn kara astaamaha ay sababaan heerarka istrogen-ka sareeya:

• Dabagal taxaddar leh
• Miisaanka oo yaraada
• Isbedelada cuntada
• Daawooyin
• Jimicsi xoog leh oo joogto ah

Dhalmo la'aan iyo dhibaatooyin xilliga uurka ayaa dhici kara.

Haweenka qaba cilladda ugxan-sidaha ee 'polycystic ovary syndrome' ayaa laga yaabaa inay halista ugu sii kordhaan:

• Sonkorowga
• Dhiig kar
• Kalastarol sare
• Cayilka
• Kansarka kaadi mareenka

Haweenka qaba cudurka ugxan-sidaha ee 'polycystic ovary syndrome' waxay yareyn karaan isbeddelladooda dhibaatooyinka muddada-dheer iyagoo ilaalinaya miisaanka caadiga ah iyadoo loo marayo cunno caafimaad leh iyo jimicsi joogto ah.

• Ugxan sidaha wax soo saar badan
• Horumarinta follicle

Bulun SE. Jir-dhiska iyo cilmiga jirrada ee dhidibka taranka dumarka. Gudaha: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Buugga Buugga Endocrinology. 14aad. Philadelphia, PA: Elsevier; 2020: cutubka 17.

Huddleston HG, Quinn M, Gibson M. Polycystic ugxan xanuunka iyo hirsutism. Gudaha: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Buugga Buugga Caafimaadka Caruurta. 21aad ed. Philadelphia, PA: Elsevier; 2020: baab 567.

Lobo RA. Hyperandrogenism iyo androgen xad-dhaaf: physiology, etiology, ogaanshaha kala duwanaanta, maaraynta. Gudaha: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Cilmiga Haweenka oo dhameystiran. 7aad ed. Philadelphia, PA: Elsevier; 2017: cutubka 40.

Rosenfield RL, Barnes RB, Ehrmann DA. Hyperandrogenism, hirsutism, iyo polycystic ugxan syndrome. Gudaha: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Dadka waaweyn iyo carruurta. 7aad ed. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 133.