Lomitapide

Qanacsan

• Kahor qaadashada lomitapide,
• Lomitapide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, jooji qaadashada lomitapide oo wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

Lomitapide waxay waxyeelo daran u geysan kartaa beerka. U sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa cudurka beerka ku dhacdo ama haddii aad waligaa dhibaato beerka ku qabatay intaad qaadanaysay daawooyinka kale.Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadin lomitapide. U sheeg dhakhtarkaaga haddii aad khamri cabto. Cabitaanka khamrigu wuxuu kordhin karaa halista aad ku yeelan karto dhibaatooyinka beerka. Ha cabin wax kabadan hal cabitaan khamri ah maalintii inta aad qaadaneysid lomitapide. U sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad qaadanaysid acetaminophen (Tylenol, kuwa kale), amiodarone (Cordarone), doxycycline (Doryx, Vibramycin, kuwa kale), isotretinoin (Accutane), methotrexate (Rheumatrex), minocycline (Dynacin, Minocin), tamoxifen ), ama tetracycline (Sumycin). Haddii aad isku aragto mid ka mid ah astaamaha soo socda waqti kasta inta lagu jiro daweyntaada, jooji qaadashada lomitapide oo isla markiiba wac dhakhtarkaaga: daal aad u daran, tamar la'aan, daciifnimo, lallabbo ama matag ka sii daraya ama aan tagaynin, xanuun dhinaca kore ee midigta ah qayb ka mid ah caloosha, rabitaanka cuntada oo yaraada, maqaarka ama indhaha oo hurdi noqda, qandho, ama astaamaha ifilada oo kale ah. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta ama uu joojiyo ama dib u dhigo daaweyntaada haddii aad la kulanto dhibaatooyin beerka ah.

Barnaamij la yiraahdo Juxtapid REMS^® waxaa ogolaaday Maamulka Cuntada iyo Maandooriyaha (FDA) sababtoo ah suurtagalnimada waxyeelo beerka oo la xiriirta isticmaalka lomitapide. Dhammaan dadka loo qoro lomitapide waa inay ka helaan dawo lomitapide dhakhtar ka diiwaangashan Juxtapid REMS^®, oo warqadda daawada laguu soo buuxiyo farmashiyaha ka diiwaan gashan Juxtapid REMS^® si loo helo daawadan.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee lomitapide.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Tilmaamaha Daawada) markaad bilawdo daaweynta lomitapide iyo markasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Lomitapide waxaa loo isticmaalaa isbeddelada cuntada (xaddidaadda kolestaroolka iyo qaadashada dufanka) iyo daaweyn kale si loo yareeyo qadarka kolestaroolka cufnaanta yar (LDL) ('kolestarool xun'), wadarta kolestaroolka, iyo walxaha kale ee dufanka leh ee ku jira dhiigga dadka kuwaas oo leh homozygous familial hypercholesterolemia (HoFH; xaalad la iska dhaxlo oo kolestaroolka jirka aan si caadi ah looga saari karin). Lomitapide looma isticmaali karo si loo yareeyo heerarka kalastarolka ee dadka aan haysan HoFH. Lomitapide waxay ku jirtaa nooc dawooyin ah oo loo yaqaan dawooyinka hoos u dhiga kolestaroolka. Waxay ku shaqeysaa iyadoo gaabineysa soosaarka kolestaroolka jirka si loo yareeyo xaddiga kolestaroolka laga yaabo inuu ku dul kaco darbiyada xididdada isla markaana xannibo socodka dhiigga ee wadnaha, maskaxda, iyo qaybaha kale ee jirka.

Ku soo ururinta kolestaroolka iyo dufanka derbiyada xididdadaada (habka loo yaqaan atherosclerosis) waxay yareyneysaa socodka dhiigga sidaas darteedna, oksijiinta wadnahaaga, maskaxdaada, iyo qeybaha kale ee jirkaaga. Hoos u dhigida heerka dhiiggaaga ee kolestaroolka iyo dufanka ayaa kaa caawin kara kahortagga cudurrada wadnaha, angina (laabta oo xanuun leh), istaroog, iyo wadno qabad.

Lomitapide waxay u timaadaa sidii kaabsol uu afka ku qaato. Waxaa badanaa la qaataa hal mar maalintii. Lomitapide waa in lagu qaataa cunto la'aan caloosha oo madhan, ugu yaraan 2 saacadood kadib cuntadaada fiidkii. Cab galaas buuxa oo biyo ah qiyaas kasta oo lomitapide ah.

Qaado lomitapide qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado lomitapide sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kaabsoosha wada liq; ha kala qaybin, calalin, ha milmin, ama ha burburin.

Waxaad u baahan doontaa inaad qaadatid fiitamiin dheeri ah inta lagaa daaweynayo lomitapide Hubso inaad si taxaddar leh u raacdo talo-bixinta uu dhakhtarkaagu kugula taliyay.

Sii wad inaad qaadatid lomitapide xitaa haddii aad caafimaad qabtid. Ha u joojin qaadashada lomitapide adigoon la hadlin dhakhtarkaaga.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada lomitapide,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay lomitapide, daawooyin kale, ama wax kasta oo ku jira kaabsoosha lomitapide. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid dawooyinka lidka ku ah fangaska sida fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), iyo voriconazole (Vfend); boceprevir (Victrelis); danaysane (Emend); ciprofloxacin (Cipro); clarithromycin (Biaxin); crizotinib (Xalkori); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S, E-Mycin, Erythrocin); Ka hortagayaasha HIV protease sida amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), saquinavir (Invira) Kaletra), ritonavir iyo tipranavir (Aptivus), iyo teleprevir (Incivek); imatinib (Gleevec); nefazodone; telithromycin (Ketek); iyo verapamil (Calan, Covera, Isoptin, Verelan). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadanin lomitapide haddii aad qaadanaysid mid ama in kabadan oo daawooyinkan ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto dawooyinka ku qoran qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: aliskiren (Tekturna); alprazolam (Xanax); ambrisentan (Letairis); amiodarone (Cordarone, Pacerone); amlodipine (Norvasc, oo ku taal Caduet); bicalutamide (Casodex); cilostazol (Pletal); dawooyinka afka qaarkood ee sonkorowga sida saxagliptin (Onglyza in Kombiglyze) iyo sitagliptin (Januvia, in Janumet); cimetidine (Tagament); colchicine (Qaylo-dhaan); dabigatran (Pradaxa); digoxin (Lanoxin); everolimus (Afinitor, Zortress); fexofenadine (Allegra); fluoxetine (Prozac); fluvoxamine (Luvox); isoniazid (INH, Nydrazid); lapatinib (Tykerb); maraviroc (Selzentry); daawooyinka xakameynaya nidaamka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) iyo tacrolimus (Prograf); nilotinib (Tasigna); p-pillerka (kaniiniyada xakameynta dhalmada); daawooyinka kale ee hoos u dhigaya kolestaroolka sida atorvastatin (Lipitor, in Caduet, in Liptruzet), lovastatin (Mevacor), and simvastatin (Zocor, in Simcor, in Vytorin); pazopanib (Votrient); ranitidine (Zantac); ranolazine (Ranexa); ticagrelor (Brilinta); tolvaptan (Samsca); topotecan (Hycamtin); warfarin (Coumadin); iyo zileuton (Zyflo). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara lomitapide, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan 'ginkgo' ama 'goldenseal'.
• haddii aad qaadanaysid cholestyramine (Questran), colesevelam (WellChol), ama colestipol (Colestid), qaado 4 saacadood ka hor ama 4 saacadood ka dib lomitapide.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa yeelatay dulqaad la’aan galactose ama malabsorption gulukoos ah (xaalado la iska dhaxlo oo jidhku uusan u dulqaadan karin laktoos), calool xanuun joogto ah ama xiidmaha, ama xammeetida ama cudurka kalyaha.
• U sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Haddii aad tahay dumar uur qaadi kara, waxaad u baahan doontaa inaad qaadatid baaritaanka uurka ka hor intaadan bilaabin qaadashada lomitapide. Haddii aad uur qaadi karto, waa inaad isticmaashaa ka hortagga uurka oo waxtar leh inta aad qaadanaysid lomitapide. Kala hadal dhakhtarkaaga hababka xakameynta dhalmada ee adiga kuu shaqeyn doona. Haddii aad uur yeelato inta aad qaadanaysid lomitapide, jooji qaadashada daawada oo isla markiiba wac dhakhtarkaaga. Lomitapide wuxuu waxyeelayn karaa uurjiifka.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso. Waa inaadan naas nuujin inta aad qaadanaysid lomitapide.

Ha cunin canab canab ah ama ha cabin casiir canab ah inta aad qaadanaysid dawadan.

Dhakhtarkaagu wuxuu kuu sheegi doonaa inaad cuntid cunto dufanku ku yar yahay. Cunista cuntada dufanka yar waxay yareyn kartaa fursadda inaad dhibaatooyin caloosha ah oo ay kujiraan lallabbo, matag, calool kacsan, iyo shuban biyood inta aad qaadaneyso lomitapide. Si taxaddar leh u raac dhammaan talooyinka nafaqada ee dhakhtarkaagu ama nafaqeeyahaagu kuu soo diro.

Ka gudub qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada ee maalinta xigta. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Lomitapide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• shuban
• lallabbo
• matagid
• calool xanuun
• calool istaag
• dibbiro
• gaaska
• calool xanuun
• miisaanka oo yaraada
• madax xanuun
• dawakhaad
• cune xanuun
• sanka oo dareera
• dhabar xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, jooji qaadashada lomitapide oo wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

• shuban daran
• madax wareer
• hoos udhaca kaadida

Lomitapide waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

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